T John Martin Selected Research

Osteoporosis

1/2018	Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.
12/2016	Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation.
11/2014	gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.
6/2014	New therapeutics for osteoporosis.
4/2012	Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo.
2/2011	Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.
2/2010	Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.
9/2005	Osteoblast-derived PTHrP is a physiological regulator of bone formation.

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T John Martin Research Topics

Disease

15	Neoplasms (Cancer) 01/2021 - 02/2002
12	Bone Resorption 01/2021 - 11/2003
8	Osteoporosis 01/2018 - 09/2005
6	Neoplasm Metastasis (Metastasis) 01/2021 - 02/2006
6	Breast Neoplasms (Breast Cancer) 01/2021 - 02/2006
6	Bone Diseases (Bone Disease) 01/2016 - 12/2007
4	Osteosarcoma (Osteogenic Sarcoma) 04/2015 - 08/2008
4	Inflammation (Inflammations) 08/2014 - 07/2004
3	Metabolic Bone Diseases (Osteopenia) 10/2021 - 02/2004
3	Humoral Hypercalcemia Of Malignancy 11/2019 - 02/2002
3	Hypercalcemia (Milk Alkali Syndrome) 06/2012 - 05/2011
2	Carcinoma (Carcinomatosis) 01/2018 - 11/2003
2	Osteolysis 04/2006 - 11/2003
2	Experimental Arthritis 07/2004 - 10/2002
1	Hypertrophy 04/2021
1	Infections 11/2014
1	Arthritis (Polyarthritis) 08/2014
1	Anemia 05/2011
1	Mesoblastic Nephroma (Congenital Mesoblastic Nephroma) 05/2011
1	Insulin Resistance 07/2009
1	Disease Susceptibility (Diathesis) 10/2008
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 12/2006
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2006
1	Chondrosarcoma 04/2002
1	Chondroma (Enchondroma) 04/2002
1	Osteochondroma (Osteocartilaginous Exostosis) 04/2002

Drug/Important Bio-Agent (IBA)

19	Parathyroid Hormone-Related ProteinIBA 10/2021 - 02/2002
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2002
6	Parathyroid Hormone (Parathormone)IBA 11/2019 - 03/2004
4	Hormones (Hormone)IBA 01/2021 - 06/2010
4	OsteoprotegerinIBA 02/2007 - 10/2002
3	CytokinesIBA 08/2014 - 01/2011
2	Interleukin-6 (Interleukin 6)IBA 10/2019 - 02/2004
2	Messenger RNA (mRNA)IBA 01/2018 - 11/2014
2	Pharmaceutical PreparationsIBA 06/2015 - 02/2010
2	Type 1 Parathyroid Hormone Receptor (Parathyroid Hormone Receptor)IBA 10/2014 - 04/2002
2	Neutralizing AntibodiesIBA 06/2009 - 02/2007
1	FollistatinIBA 04/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	A-factor (Streptomyces)IBA 01/2021
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2021
1	abaloparatideIBA 01/2018
1	amino-terminal parathyroid hormoneIBA 01/2018
1	Cyclic AMP (AMP, Cyclic)IBA 01/2018
1	Coloring Agents (Dyes)IBA 01/2018
1	Teriparatide (Parathar)FDA Link 01/2018
1	RetinoidsIBA 01/2016
1	RecQ HelicasesIBA 04/2015
1	Complement System Proteins (Complement)IBA 10/2014
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 10/2014
1	Oncostatin MIBA 08/2014
1	AntigensIBA 08/2014
1	Anabolic AgentsIBA 06/2014
1	Small Interfering RNA (siRNA)IBA 07/2013
1	Erythropoietin FDA Link 05/2011
1	Calcitriol (Calcijex)FDA LinkGeneric 05/2011
1	Pamidronate (Aredia)FDA LinkGeneric 05/2011
1	Furosemide (Lasix)FDA LinkGeneric 05/2011
1	MineralsIBA 05/2011
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 05/2011
1	CalciumIBA 05/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2011
1	Progesterone FDA LinkGeneric 06/2010
1	LigandsIBA 01/2010
1	Biological ProductsIBA 01/2010
1	Insulin (Novolin)FDA Link 07/2009
1	OsteocalcinIBA 07/2009
1	Glucose (Dextrose)FDA LinkGeneric 07/2009
1	Chemotactic FactorsIBA 05/2009
1	Interleukin-23 (Interleukin 23)IBA 10/2008
1	RNA (Ribonucleic Acid)IBA 08/2008
1	Estrogens (Estrogen)FDA Link 09/2007
1	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 02/2007
1	RANK LigandIBA 02/2007
1	Activating Transcription Factor 4IBA 12/2006
1	Dietary ProteinsIBA 12/2006
1	Progesterone Receptors (Progesterone Receptor)IBA 02/2006
1	Estrogen ReceptorsIBA 02/2006
1	Zoledronic Acid (Zometa)FDA Link 07/2004
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 04/2004
1	Diphosphonates (Bisphosphonates)IBA 11/2003
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 11/2003

Therapy/Procedure

10	Therapeutics 01/2018 - 12/2006
1	Intramuscular Injections 04/2021
1	Chemoprevention 06/2010
1	Fracture Fixation 01/2007